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- Table of Contents
Facts about Phospholipase DDHD2.
May be involved in the upkeep of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.
Human | |
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Gene Name: | DDHD2 |
Uniprot: | O94830 |
Entrez: | 23259 |
Belongs to: |
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PA-PLA1 family |
DDHD domain containing 2; DDHD domain-containing protein 2; EC 3.1.1.-; KIAA0725PA-PLA1 like; phospholipase DDHD2; SAM, WWE and DDHD domain containing 1; SAM, WWE and DDHD domain-containing protein 1; SAMWD1; sec23p-interacting protein p125-like phosphatidic acid-preferring phospholipaseA1
Mass (kDA):
81.032 kDA
Human | |
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Location: | 8p11.23 |
Sequence: | 8; NC_000008.11 (38231491..38273922) |
Widely expressed (at protein level).
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P.
PMID: 11788596 by Nakajima K., et al. A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125.
PMID: 15623529 by Shimoi W., et al. p125 is localized in endoplasmic reticulum exit sites and involved in their organization.