Differentially expressed in FDCP 6 (Def6)

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in collaboration with activated RAC1.

Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimum T-cell effector function, lymphocyte homeostasis and the avoidance of systemic autoimmunity (By similarity).