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Def6 Antibodies
AND Def6 ELISA kits, Def6 Proteins
Many biological assays use antibodies to detect Def6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Def6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Def6 antibodies...
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Def6 Infographic by Boster Bio
All Def6 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M06058
100 µl
Cat # M06058
100 µl
Human, Mouse
ELISA, Flow Cytometry, IP, IF, ICC, WB
$370
Cat # A06058-3
100 μg/vial
Cat # A06058-3
100 μg/vial
Def6 Overview
Facts about Differentially expressed in FDCP 6.
Differentially expressed in FDCP 6 (Def6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in collaboration with activated RAC1.
Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimum T-cell effector function, lymphocyte homeostasis and the avoidance of systemic autoimmunity (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Def6 |
| Uniprot: | Q8C2K1 |
| Entrez: | 23853 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DEF-6; differentially expressed in FDCP 6 homolog (mouse); differentially expressed in FDCP 6 homolog; IBPdifferentially expressed in FDCP (mouse homolog) 6; IRF4-binding protein; SLAT; SWAP70L; SWAP-70-like adaptor protein of T cells
Molecular Weight
Mass (kDA):
73.454 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17|17 A3.3 |
| Sequence: | 17; |
Tissue Specificity
Thymus.
Diseases
- Autoimmunity
- Autoimmune Reaction
- Autoimmune Diseases
- Neoplasms
- Lupus Erythematosus, Systemic
- Experimental Autoimmune Encephalomyelitis
- Inflammation
- Malignant Neoplasms
- Encephalomyelitis
- Malignant Paraganglionic Neoplasm
- Adenoma
- Malignant Neoplasm Of Breast
Pathways
- Cell Activation
- T Cell Activation
- Cell Proliferation
- Pathogenesis
- Localization
- T Cell Proliferation
- Cell Differentiation
- Gastrulation
- Convergent Extension
- Cell Development
- T Cell Homeostasis
- Plasma Cell Differentiation
- Lymphocyte Homeostasis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Def6
bosterbio.com/bosterbio-gene-info-cards/Def6
References
PMID: 12648457 by Tanaka Y., et al. SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.
PMID: 12651066 by Gupta S., et al. Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.