DENND2B Antibodies

AND DENND2B ELISA kits, DENND2B Proteins

Many biological assays use antibodies to detect DENND2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DENND2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DENND2B antibodies...

We validate the specificity of these antibodies to DENND2B by testing them on tissues known to express DENND2B positively and negatively. Browse below to find the DENND2B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DENND2B Infographic by Boster Bio

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DENND2B (NM_005418) Human Over-expression Lysate

DENND2B Human Over-expression Lysates NM_005418

Human

$960
Cat # LS006764
20 µg, 100 µg

DENND2B Overview

Facts about DENN domain-containing protein 2B.

DENND2B 3D structure. Source: alphafold

DENN domain-containing protein 2B (DENND2B)

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins in their active GTP- bound form.

May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2.

Gene Information

Human
Gene Name:	DENND2B
Uniprot:	P78524
Entrez:	6764

Family

Belongs to:

No superfamily

Alternative Names

DENN domain-containing protein 2B

Molecular Weight

Mass (kDA):
126.485 kDA

Genomic Context


Human

Location:	11p15.4
Sequence:	11; NC_000011.10 (8693352..8910951, complement)

Tissue Specificity

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level).

Subcellular Localizations

[Isoform 1]: Cytoplasm, cell cortex. Cell membrane. Recycling endosome. Colocalizes with RAB13 and ITSN1 at cytoplasmic vesicles that are most likely recycling endosomes. Colocalizes with the cortical actin cytoskeleton.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DENND2B

References

PMID: 8972856 by Lichy J.H., et al. Differential expression of the human ST5 gene in HeLa-fibroblast hybrid cell lines mediated by YY1: evidence that YY1 plays a part in tumor suppression.

PMID: 11528127 by Amid C., et al. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7.