DENND3 Antibodies

AND DENND3 ELISA kits, DENND3 Proteins

Many biological assays use antibodies to detect DENND3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DENND3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DENND3 antibodies...

We validate the specificity of these antibodies to DENND3 by testing them on tissues known to express DENND3 positively and negatively. Browse below to find the DENND3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DENND3 Infographic by Boster Bio

All DENND3 Products

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DENND3 (NM_014957) Human Over-expression Lysate

Human

$960
Cat # LS022898
20 µg, 100 µg

DENND3 Overview

Facts about DENN domain-containing protein 3.

DENN domain-containing protein 3 (DENND3)

Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 to its active GTP-bound form (PubMed:20937701).

Regulates autophagy in response to starvation through RAB12 activation. Starvation contributes to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and contributes to up-regulation of GEF activity towards RAB12 (By similarity).

Gene Information

Human
Gene Name:	DENND3
Uniprot:	A2RUS2
Entrez:	22898

Family

Belongs to:

No superfamily

Alternative Names

DENN/MADD domain containing 3; KIAA0870DENN domain-containing protein 3

Molecular Weight

Mass (kDA):
135.89 kDA

Genomic Context


Human

Location:	8q24.3
Sequence:	8; NC_000008.11 (141128562..141195804)

Subcellular Localizations

Cytoplasm. Transiently recruited to membranes to activate RAB12.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DENND3

References

PMID: 20937701 by Yoshimura S., et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.