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May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive excellent control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908).
|Sequence:||17; NC_000017.11 (5471254..5486225, complement)|
Ubiquitous. Overexpressed in various hepatocarcinomas.
Endoplasmic reticulum membrane; Multi-pass membrane protein.