Dickkopf-related protein 1 (Dkk1)

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087).

Plays a role in limb development; attenuates Wnt signaling in the developing limb to permit normal limb patterning (PubMed:18505822). .