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- Table of Contents
Facts about Dickkopf-like protein 1.
In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility.
Human | |
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Gene Name: | DKKL1 |
Uniprot: | Q9UK85 |
Entrez: | 27120 |
Belongs to: |
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No superfamily |
Cancer/testis antigen 34; CT34dickkopf-like 1 (soggy); dickkopf-like 1; DkkL1; Protein soggy-1; SGY; SGY1; SGY-1dickkopf-like protein 1; SGY1soggy; Soggy1; Soggy-1
Mass (kDA):
27.007 kDA
Human | |
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Location: | 19q13.33 |
Sequence: | 19; NC_000019.10 (49360520..49375132) |
More highly expressed in adult testis than in fetal testis. Exclusively expressed in the testis (at protein level). Intense expression in stages II, III and IV of spermatogenesis, whereas expression is lower in stage I.
Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome. Localized specifically to the crescent shaped acrosome at the apex of the sperm head.
PMID: 10570958 by Krupnik V.E., et al. Functional and structural diversity of the human Dickkopf gene family.
PMID: 22817830 by Yan Q., et al. Developmental expression and function of DKKL1/Dkkl1 in humans and mice.