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- Table of Contents
DNMT3L Antibodies
AND DNMT3L ELISA kits, DNMT3L Proteins
Many biological assays use antibodies to detect DNMT3L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNMT3L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNMT3L antibodies...
Designing a Western blot for DNMT3L? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DNMT3L Western Blot GuideDNMT3L Infographic by Boster Bio
All DNMT3L Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A04214-3
100 μg/vial
Cat # A04214-3
100 μg/vial
DNMT3L Overview
Facts about DNA (cytosine-5)-methyltransferase 3-like.
DNA (cytosine-5)-methyltransferase 3-like (DNMT3L)
Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation based on the circumstance (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327).
Acts by hastening the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex following DNA binding to the methyltransferases (PubMed:17687327). Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by activation or recruitment of DNMT3 (PubMed:17687327).
Gene Information
| Human | |
|---|---|
| Gene Name: | DNMT3L |
| Uniprot: | Q9UJW3 |
| Entrez: | 29947 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; human cytosine-5-methyltransferase 3-like protein, 10cytosine-5-methyltransferase 3-like protein; MGC1090
Molecular Weight
Mass (kDA):
43.583 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.3 |
| Sequence: | 21; NC_000021.9 (44246339..44261897, complement) |
Tissue Specificity
Expressed at low levels in several tissues including testis, ovary, and thymus.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Testicular Neoplasms
- Infertility
- Male Infertility
- Carcinoma
- Immunologic Deficiency Syndromes
- Germ Cell Tumor
- Beckwith-wiedemann Syndrome
- Embryonal Carcinoma
- Azoospermia
- Testicular Germ Cell Tumor
Interacting Proteins
- DNMT3A
- HDAC1
- RSL24D1
Pathways
- Methylation
- Dna Methylation
- Spermatogenesis
- Germ Cell Development
- Cell Development
- Meiosis
- Demethylation
- Oogenesis
- Localization
- Maintenance Of Dna Methylation
- Oocyte Growth
- Dna Replication
- Histone Modification
PTMs
- Methylation
- Demethylation
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DNMT3L
bosterbio.com/bosterbio-gene-info-cards/DNMT3L
References
PMID: 10857753 by Aapola U., et al. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family.
PMID: 17687327 by Ooi S.K., et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.