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- Table of Contents
Facts about Double C2-like domain-containing protein alpha.
May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in lack of action potentials in neuronal cells.
Human | |
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Gene Name: | DOC2A |
Uniprot: | Q14183 |
Entrez: | 8448 |
Belongs to: |
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No superfamily |
Doc2 alpha; Doc2; DOC2A; doc2-alpha; double C2-like domain-containing protein alpha; double C2-like domains, alpha
Mass (kDA):
43.959 kDA
Human | |
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Location: | 16p11.2 |
Sequence: | 16; NC_000016.10 (30005514..30023280, complement) |
Predominantly expressed in brain. Also expressed in testis.
Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome.
PMID: 7826360 by Orita S., et al. Doc2, a novel synaptic vesicle protein with two repeated C2-like domains.
PMID: 8554557 by Sakaguchi G., et al. Molecular cloning of an isoform of Doc2 having two C2-like domains.