Dedicator of cytokinesis protein 1 (DOCK1)

Involved in cytoskeletal rearrangements necessary for phagocytosis of apoptotic cells and cell motility. Together with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity could be improved by ELMO1 (PubMed:8657152).