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- Table of Contents
DOCK1 Antibodies
AND DOCK1 ELISA kits, DOCK1 Proteins
Many biological assays use antibodies to detect DOCK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DOCK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DOCK1 antibodies...
Designing an IHC experiment for DOCK1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the DOCK1 IHC GuideDOCK1 Infographic by Boster Bio
All DOCK1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A03440-2
100 μg/vial
Cat # A03440-2
100 μg/vial
DOCK1 Overview
Facts about Dedicator of cytokinesis protein 1.
Dedicator of cytokinesis protein 1 (DOCK1)
Involved in cytoskeletal rearrangements necessary for phagocytosis of apoptotic cells and cell motility. Together with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity could be improved by ELMO1 (PubMed:8657152).
Gene Information
| Human | |
|---|---|
| Gene Name: | DOCK1 |
| Uniprot: | Q14185 |
| Entrez: | 1793 |
Family
| Belongs to: |
|---|
| DOCK family |
Alternative Names
180 kDa protein downstream of CRK; ced5; dedicator of cytokinesis 1; dedicator of cyto-kinesis 1; DOCK1; DOCK180; DOCK180dedicator of cytokinesis protein 1; DOwnstream of CrK
Molecular Weight
Mass (kDA):
215.346 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.2 |
| Sequence: | 10; NC_000010.11 (126905428..127452517) |
Tissue Specificity
Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Subcellular Localizations
Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.
Diseases
- Tissue Adhesions
- Neoplasms
- Cell Invasion
- Malignant Neoplasms
- Neoplasm Invasiveness
- Malignant Paraganglionic Neoplasm
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Malignant Neoplasm Of Brain
- Glioma
- Immunologic Tolerance
- Carcinoma
- Tumor Angiogenesis
Interacting Proteins
- ANKRD28
- ELMO1
- GRB2
- RAC1
Pathways
- Cell Migration
- Phagocytosis
- Cell Motility
- Localization
- Myoblast Fusion
- Cytokinesis
- Cell Adhesion
- Dorsal Closure
- Cell Cycle
- Cell Growth
- Actin Cytoskeleton Reorganization
- Cell Proliferation
- Regulation Of Cell Motility
PTMs
- Phosphorylation
- Biotinylation
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOCK1
bosterbio.com/bosterbio-gene-info-cards/DOCK1
References
PMID: 8657152 by Hasegawa H., et al. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.
PMID: 8662907 by Matsuda M., et al. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.