DONSON Antibodies

AND DONSON ELISA kits, DONSON Proteins

Many biological assays use antibodies to detect DONSON, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DONSON in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DONSON antibodies...

We validate the specificity of these antibodies to DONSON by testing them on tissues known to express DONSON positively and negatively. Browse below to find the DONSON antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DONSON Infographic by Boster Bio

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DONSON Overview

Facts about Protein downstream neighbor of Son.

DONSON 3D structure. Source: alphafold

Protein downstream neighbor of Son (DONSON)

Replisome component that maintains genome stability by protecting stalled or damaged replication forks. Following the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra- S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.

Gene Information

Human
Gene Name:	DONSON
Uniprot:	Q9NYP3
Entrez:	29980

Family

Belongs to:

DONSON family

Alternative Names

B17; downstream neighbor of SON; protein downstream neighbor of Son

Molecular Weight

Mass (kDA):
62.747 kDA

Genomic Context


Human

Location:	21q22.11
Sequence:	21; NC_000021.9 (33577551..33588684, complement)

Tissue Specificity

Expressed in the brain, with higher levels in prenatal compared to adult brain.

Subcellular Localizations

Nucleus. Localizes at DNA replication sites.

Diseases

Microcephaly-micromelia syndrome (MIMIS)

Pathways

Mrna Processing
Rna Interference

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DONSON

References

PMID: 10773462 by Slavov D., et al. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21.

PMID: 28630177 by Evrony G.D., et al. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.