DPM1 Antibodies

AND DPM1 ELISA kits, DPM1 Proteins

Many biological assays use antibodies to detect DPM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DPM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DPM1 antibodies...

We validate the specificity of these antibodies to DPM1 by testing them on tissues known to express DPM1 positively and negatively. Browse below to find the DPM1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DPM1 Infographic by Boster Bio

All DPM1 Products

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Specificity

Applications

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Anti-DPM1 Antibody

Western blot analysis of extracts of various cell lines, using DPM1 antibody at 1:1000 dilution

Immunofluorescence analysis of U2OS cells using DPM1 antibody at dilution of 1:100

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A05597
100ul

DPM1 (NM_003859) Human Over-expression Lysate

Human

$628
Cat # LS008813
20 µg, 100 µg

Anti-DPM1 antibody

Human

ELISA, IHC, WB

$370
Cat # A05597-2
100 μl/vial

DPM1 Overview

Facts about Dolichol-phosphate mannosyltransferase subunit 1.

DPM1 3D structure. Source: alphafold

Dolichol-phosphate mannosyltransferase subunit 1 (DPM1)

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex. .

Gene Information

Human
Gene Name:	DPM1
Uniprot:	O60762
Entrez:	8813

Family

Belongs to:

glycosyltransferase 2 family

Alternative Names

CDGIEEC 2.4.1.83; dolichol monophosphate mannose synthase; dolichol-phosphate mannosyltransferase; Dolichyl-phosphate beta-D-mannosyltransferase; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; DPM synthase; Mannose-P-dolichol synthase; MPD synthase; MPDSDolichol-phosphate mannose synthase

Molecular Weight

Mass (kDA):
29.634 kDA

Genomic Context


Human

Location:	20q13.13
Sequence:	20; NC_000020.11 (50934855..50958564, complement)

Subcellular Localizations

Endoplasmic reticulum.

Diseases

Congenital Disorders
Congenital Disorders Of Glycosylation
Developmental Delay (disorder)
Microcephaly
Developmental Disabilities
Neoplasms
Lymphoma
Muscular Dystrophy
Optic Atrophy
Charge Syndrome
Atresia
Respiratory Papillomatosis

Thymus Neoplasms
Polyps
Ataxia
Alpha-dystroglycanopathies
Thymoma
Resectable Pancreatic Cancer

Interacting Proteins

DPM3
TDO2

Pathways

Glycosylation
Protein Glycosylation
Protein Secretion
Secretion
Localization
Protein Phosphorylation
Secretory Pathway
Transport
Protein Mannosylation
Cell Proliferation
Induction Of Apoptosis
Endothelial Cell Proliferation

Dentinogenesis
Lipid Glycosylation
Cell Cycle
Cell Growth
Mating
Angiogenesis
Invasive Growth

PTMs

Glycosylation
Gpi Anchoring
Phosphorylation

Cleavage
C-mannosylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DPM1

References

PMID: 9535917 by Tomita S., et al. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells.

PMID: 9223280 by Colussi P.A., et al. Human and Saccharomyces cerevisiae dolichol phosphate mannose synthases represent two classes of the enzyme, but both function in Schizosaccharomyces pombe.