Destrin Antibodies

AND DSTN ELISA kits, Destrin Proteins

Many biological assays use antibodies to detect Destrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Destrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Destrin antibodies...

We validate the specificity of these antibodies to Destrin by testing them on tissues known to express DSTN positively and negatively. Browse below to find the DSTN antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Destrin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the DSTN IHC Guide

DSTN Infographic by Boster Bio

All DSTN Products

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Figures

Specificity

Applications

Price

Anti-Destrin Rabbit Monoclonal Antibody

Immunofluorescent analysis using the Antibody at 1:50 dilution

Immunofluorescent analysis using the Antibody at 1:150 dilution

IHC analysis of Destrin using anti-Destrin antibody (M03849-2)

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M03849-2
100 μl/vial

Destrin (DSTN) (NM_006870) Human Over-expression Lysate

Destrin (DSTN) Human Over-expression Lysates NM_001011546

Human

$628
Cat # LS011034
20 µg, 100 µg

Destrin (DSTN) (NM_006870) Human Recombinant Protein

Coomassie blue staining of purified DSTN protein

$1249
Cat # PROTP60981
20 µg

DSTN Overview

Facts about Destrin.

DSTN 3D structure. Source: alphafold

Destrin (DSTN)

Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin).

Acts in a pH- independent manner. .

Gene Information

Human
Gene Name:	DSTN
Uniprot:	P60981
Entrez:	11034

Family

Belongs to:

actin-binding proteins ADF family

Alternative Names

ACTDPdestrin; Actin-depolymerizing factor; ADFbA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); bA462D18.2; destrin (actin depolymerizing factor); DSN

Molecular Weight

Mass (kDA):
18.506 kDA

Genomic Context


Human

Location:	20p12.1
Sequence:	20; NC_000020.11 (17569173..17609919)

Tissue Specificity

Widely distributed in various tissues.

Diseases

Corneal Diseases
Pathologic Neovascularization
Inflammation
Malignant Neoplasms
Neoplasms
Chimera Disorder
Prostatic Neoplasms
Nervousness
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Leukemia
Kidney Diseases
Salmonella Infections

Alzheimer's Disease
Neoplasm Metastasis
Down Syndrome
Neuronal Migration Disorders
Infertility
Tumor Angiogenesis
Myeloid Leukemia

Interacting Proteins

ACTB
ACTG1
TAX1BP1

Pathways

Localization
Cell Motility
Cell Migration
Cytokinesis
Cell Proliferation
Actin Filament Depolymerization
Response To Ph
Endocytosis
Transport
Neural Tube Closure
Pollen Development
Neural Crest Cell Migration
Microtubule Sliding

Proteolysis
Tube Morphogenesis
Lymphangiogenesis
Spermatogenesis
Nuclear Transport
Cell Division
Cytoskeleton Organization

PTMs

Phosphorylation

Dephosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DSTN

References

PMID: 8399167 by Hawkins M., et al. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments.

PMID: 11812157 by Yeoh S., et al. Determining the differences in actin binding by human ADF and cofilin.