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- Table of Contents
Facts about Dual specificity protein phosphatase 12.
Has phosphatase activity with the artificial substrate 6,8-difluoro-4- methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476). .
Human | |
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Gene Name: | DUSP12 |
Uniprot: | Q9UNI6 |
Entrez: | 11266 |
Belongs to: |
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protein-tyrosine phosphatase family |
dual specificity phosphatase 12; dual specificity protein phosphatase 12; Dual specificity tyrosine phosphatase YVH1; DUSP1YVH1 protein-tyrosine phosphatase ortholog; EC 3.1.3.48; serine/threonine specific protein phosphatase; TDSP4; YVH1EC 3.1.3.16
Mass (kDA):
37.687 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (161749786..161757238) |
Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.
Nucleus. Cytoplasm, cytosol. Primarily nuclear. Detected in a mesh-like pattern in the cytosol.
PMID: 10446167 by Muda M., et al. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function.
PMID: 24531476 by Jeong D.G., et al. The family-wide structure and function of human dual-specificity protein phosphatases.