DNA excision repair protein ERCC-1 (ERCC1)

Isoform 1: Non-catalytic part of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).

Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can lead to cytokinesis failure. Also required for homology-directed fix (HDR) of DNA double-strand breaks, in combination with SLX4.