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- Table of Contents
ERCC1 Antibodies
AND ERCC1 ELISA kits, ERCC1 Proteins
Many biological assays use antibodies to detect ERCC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ERCC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ERCC1 antibodies...
Designing a Western blot for ERCC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ERCC1 Western Blot GuideERCC1 Infographic by Boster Bio
All ERCC1 Products
Product
Figures
Specificity
Applications
Price
Anti-ERCC1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00388-3
100 μg/vial
Cat # A00388-3
100 μg/vial
Human, Mouse
ELISA
$480
Cat # EKC1199
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1199
1 kit, containing one 96-well plate and all necessary reagents
ERCC1 Overview
Facts about DNA excision repair protein ERCC-1.
DNA excision repair protein ERCC-1 (ERCC1)
Isoform 1: Non-catalytic part of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL).
Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can lead to cytokinesis failure. Also required for homology-directed fix (HDR) of DNA double-strand breaks, in combination with SLX4.
Gene Information
| Human | |
|---|---|
| Gene Name: | ERCC1 |
| Uniprot: | P07992 |
| Entrez: | 2067 |
Family
| Belongs to: |
|---|
| ERCC1/RAD10/SWI10 family |
Alternative Names
COFS4; DNA excision repair protein ERCC-1; ERCC1; excision repair cross-complementing rodent repair deficiency, complementationgroup 1 (includes overlapping antisense sequence); RAD10; UV20
Molecular Weight
Mass (kDA):
32.562 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (45407334..45451547, complement) |
Subcellular Localizations
[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Nucleus.; [Isoform 4]: Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Carcinoma
- Adenocarcinoma
- Xeroderma Pigmentosum
- Xeroderma
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Malignant Squamous Cell Neoplasm
- Colorectal Cancer
Interacting Proteins
- EGFR
- ERCC4
- MKRN3
- SLX4
- TRMT2B
- UBL7
- USHBP1
- VPS37B
- XPA
Pathways
- Dna Repair
- Drug Resistance
- Cell Cycle
- Aging
- Mismatch Repair
- Dna Replication
- Methylation
- Dna Excision
- Cell Death
- Cell Proliferation
- Reverse Transcription
- Hypersensitivity
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Demethylation
- Oxidation
Research Areas
- Cancer
- DNA Repair
- Nucleotide Excision Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ERCC1
bosterbio.com/bosterbio-gene-info-cards/ERCC1
References
PMID: 2420469 by van Duin M., et al. Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.
PMID: 3034490 by Hoeijmakers J.H.J., et al. Identification of DNA repair genes in the human genome.