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ETHE1 absorbs molecular oxygen to catalyze the oxidation of the persulfide, once it's been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, because of the inhibition of cytochrome c oxidase.
|Sequence:||19; NC_000019.10 (43506719..43527201, complement)|
Cytoplasm. Nucleus. Mitochondrion matrix.