FBXW8 Antibodies

AND FBXW8 ELISA kits, FBXW8 Proteins

Many biological assays use antibodies to detect FBXW8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FBXW8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FBXW8 antibodies...

We validate the specificity of these antibodies to FBXW8 by testing them on tissues known to express FBXW8 positively and negatively. Browse below to find the FBXW8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FBXW8 Infographic by Boster Bio

All FBXW8 Products

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FBXW8 (NM_153348) Human Over-expression Lysate

FBXW8 Human Over-expression Lysates NM_012174

Human

$628
Cat # LS026259
20 µg, 100 µg

Anti-FBXW8 Antibody Picoband®

Western blot analysis of FBXW8 using anti-FBXW8 antibody (A06760-1)

Human, Rat

ELISA, WB

$370
Cat # A06760-1
100 μg/vial

FBXW8 Overview

Facts about F-box/WD repeat-containing protein 8.

FBXW8 3D structure. Source: alphafold

F-box/WD repeat-containing protein 8 (FBXW8)

Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988).

Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026).

Gene Information

Human
Gene Name:	FBXW8
Uniprot:	Q8N3Y1
Entrez:	26259

Family

Belongs to:

No superfamily

Alternative Names

F-box and WD repeat domain containing 8; F-box only protein 29F-box/WD repeat-containing protein 8; FBW8F-box and WD-40 domain-containing protein 8; FBX29MGC33534; FBXO29; FBXW6FBW6F-box and WD-40 domain protein 8