Formin-like protein 1 Antibodies

AND FMNL1 ELISA kits, Formin-like protein 1 Proteins

Many biological assays use antibodies to detect Formin-like protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Formin-like protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Formin-like protein 1 antibodies...

We validate the specificity of these antibodies to Formin-like protein 1 by testing them on tissues known to express FMNL1 positively and negatively. Browse below to find the FMNL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FMNL1 Infographic by Boster Bio

All FMNL1 Products

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Price

FMNL1 (NM_005892) Human Over-expression Lysate

Human

$960
Cat # LS000752
20 µg, 100 µg

Anti-FMNL1 Antibody Picoband®

Western blot analysis of FMNL1 using anti-FMNL1 antibody (A05377-1)

Mouse

ELISA, WB

$370
Cat # A05377-1
100 μg/vial

FMNL1 Overview

Facts about Formin-like protein 1.

FMNL1 3D structure. Source: alphafold

Formin-like protein 1 (FMNL1)

May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization.

Required from the cortical actin filament dynamics and cell shape. .

Gene Information

Human
Gene Name:	FMNL1
Uniprot:	O95466
Entrez:	752

Family

Belongs to:

formin homology family

Alternative Names

C17orf1BMGC133052; C17orf1KW-13; CLL-associated antigen KW-13; FHOD4; FMNLMGC1894; formin-like 1; formin-like protein 1; formin-like; Leukocyte formin; MGC21878

Molecular Weight

Mass (kDA):
121.854 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (45220268..45247322)

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).; [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Colocalized with F-actin in bleb protrusions.

Diseases

Malignant Neoplasms
Chondrosarcoma
Neoplasms
Lymphoma
Malignant Neoplasm Of Pancreas
Chronic Lymphocytic Leukemia
Cell Invasion
Glioblastoma
Leukemia
Lymphoid Leukemia
Melanoma
Carcinogenesis
Carcinoma

Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Burkitt Lymphoma
Malignant Neoplasm Of Breast
Breast Adenocarcinoma
Parathyroid Neoplasms
Leukemia, Myelocytic, Acute

Interacting Proteins

HMG20A
SRGAP2

Pathways

Localization
Cell Adhesion
Cell Activation
T Cell Activation
Glycosylation
Cytokinesis
Actin Filament Severing
Cell Division
Phagocytosis
Cellular Localization

Limb Morphogenesis
Monocyte Differentiation
Tissue Homeostasis
Actin Nucleation

PTMs

Phosphorylation

Glycosylation

Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FMNL1

References

PMID: 9799091 by Aronsson F.C., et al. The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.

PMID: 19815554 by Han Y., et al. Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.