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- Table of Contents
FOXA2 Antibodies
AND FOXA2 ELISA kits, FOXA2 Proteins
Many biological assays use antibodies to detect FOXA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FOXA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FOXA2 antibodies...
Designing a Western blot for FOXA2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXA2 Western Blot GuideFOXA2 Infographic by Boster Bio
All FOXA2 Products
Product
Figures
Specificity
Applications
Price
Anti-FOXA2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01032-2
100 μg/vial
Cat # A01032-2
100 μg/vial
FOXA2 Overview
Facts about Hepatocyte nuclear factor 3-beta.
Hepatocyte nuclear factor 3-beta (FOXA2)
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a'pioneer' variable opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at goal enhancer and/or promoter sites.
Binds DNA using the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXA2 |
| Uniprot: | Q9Y261 |
| Entrez: | 3170 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
forkhead box A2; Forkhead box protein A2; FoxA2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; hepatocyte nuclear factor 3-beta; HNF3 beta; HNF-3 beta; HNF-3B; HNF-3-beta; HNF3BTCF-3B; MGC19807; TCF3B; Transcription factor 3B
Molecular Weight
Mass (kDA):
48.306 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p11.21 |
| Sequence: | 20; NC_000020.11 (22580998..22585490, complement) |
Subcellular Localizations
Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
Diseases
- Diabetes Mellitus
- Liver Carcinoma
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Carcinoma
- Liver Neoplasms
- Insulin Resistance
- Adenocarcinoma
- Hyperplasia
- Obesity
- Inflammation
- Prostatic Neoplasms
Pathways
- Secretion
- Cell Differentiation
- Gastrulation
- Insulin Secretion
- Glucose Homeostasis
- Localization
- Endoderm Formation
- Cell Proliferation
- Pancreas Development
- Transport
- Pathogenesis
- Liver Development
- Endoderm Development
PTMs
- Phosphorylation
- Methylation
- Oxidation
- Cleavage
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXA2
bosterbio.com/bosterbio-gene-info-cards/FOXA2
References
PMID: 10672453 by Yamada S., et al. Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
PMID: 10899756 by Navas M.A., et al. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.