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- Table of Contents
FOXA3 Antibodies
AND FOXA3 ELISA kits, FOXA3 Proteins
Many biological assays use antibodies to detect FOXA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FOXA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FOXA3 antibodies...
Designing a Western blot for FOXA3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXA3 Western Blot GuideDesigning an IHC experiment for FOXA3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the FOXA3 IHC GuideFOXA3 Infographic by Boster Bio
All FOXA3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9805
100 μg/vial
Cat # PB9805
100 μg/vial
FOXA3 Overview
Facts about Hepatocyte nuclear factor 3-gamma.
Hepatocyte nuclear factor 3-gamma (FOXA3)
Transcription factor that is thought to serve as a'pioneer' factor opening the compacted chromatin for different proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver enzymes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc.
Interacts with the cis-acting regulatory regions of these genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXA3 |
| Uniprot: | P55318 |
| Entrez: | 3171 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; hepatocyte nuclear factor 3, gamma; hepatocyte nuclear factor 3-gamma; HNF-3G; HNF-3-gamma; HNF3GTCF-3G; MGC10179; TCF3G; Transcription factor 3G
Molecular Weight
Mass (kDA):
37.14 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.32 |
| Sequence: | 19; NC_000019.10 (45864326..45873797) |
Tissue Specificity
Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.
Subcellular Localizations
Nucleus.
Diseases
- Liver Carcinoma
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Liver Neoplasms, Experimental
- Hepatitis B
- Hepatitis
- Metaplasia
- Inflammation
- Liver Neoplasms
- Liver Diseases
- Injury To Liver
- Hypoglycemia
Pathways
- Glucose Homeostasis
- Secretion
- Cell Differentiation
- Regulation Of Gene Expression
- Cell Activation
- Cell Proliferation
- Pathogenesis
- Liver Development
- Sensitization
- Gastrulation
- Insulin Secretion
- Hepatocyte Differentiation
- T Cell Activation
PTMs
- Phosphorylation
- Carboxylation
- Reduction
- Deamination
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXA3
bosterbio.com/bosterbio-gene-info-cards/FOXA3
References
PMID: 8499623 by Hromas R., et al. Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells.
PMID: 10899756 by Navas M.A., et al. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.