Hepatocyte nuclear factor 3-gamma (FOXA3)

Transcription factor that is thought to serve as a'pioneer' factor opening the compacted chromatin for different proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver enzymes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc.

Interacts with the cis-acting regulatory regions of these genes.