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- Table of Contents
Forkhead box protein O1 Antibodies
AND FOXO1 ELISA kits, Forkhead box protein O1 Proteins
Many biological assays use antibodies to detect Forkhead box protein O1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein O1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein O1 antibodies...
Designing a Western blot for Forkhead box protein O1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FOXO1 Western Blot GuideFOXO1 Infographic by Boster Bio
All FOXO1 Products
Product
Figures
Specificity
Applications
Price
Anti-FoxO1a Rabbit Monoclonal Antibody
5 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00073
100 μl
Cat # M00073
100 μl
Anti-FOXO1 Rabbit Monoclonal Antibody
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M00073-1
100 μl/vial
Cat # M00073-1
100 μl/vial
Human, Mouse
ELISA, IP, IF, IHC, WB
$146
Cat # M00073-3
20μL, 40μL, 100μL, 200μL
Cat # M00073-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00073S319
100ul
Cat # A00073S319
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00073S322S325
100ul
Cat # A00073S322S325
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00073T24-1
100ul
Cat # A00073T24-1
100ul
Human, Mouse, Rat
ELISA, IF, ICC, WB
$481
Cat # A00073
0.1 mg
Cat # A00073
0.1 mg
Human, Mouse, Rat
ELISA
$540
Cat # EKC2411
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2411
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2410
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2410
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2072
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2072
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1930
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1930
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1223
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1223
1 kit, containing one 96-well plate and all necessary reagents
FOXO1 Overview
Facts about Forkhead box protein O1.
Forkhead box protein O1 (FOXO1)
Transcription factor that's the main goal of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the associated Daf-16 household binding component (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'.
Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXO1 |
| Uniprot: | Q12778 |
| Entrez: | 2308 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FKH1; FKHR; FKHRforkhead box protein O1; forkhead box O1; Forkhead box protein O1A; forkhead homolog in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma; FoxO1; FOXO1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma
Molecular Weight
Mass (kDA):
69.662 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.11 |
| Sequence: | 13; NC_000013.11 (40555667..40666641, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upo
Diseases
- Neoplasms
- Malignant Neoplasms
- Diabetes Mellitus
- Insulin Resistance
- Rhabdomyosarcoma
- Alveolar Rhabdomyosarcoma
- Obesity
- Diabetes Mellitus, Non-insulin-dependent
- Cell Transformation, Neoplastic
- Chromosomal Translocation
- Atrophy
- Muscular Atrophy
- Insulin Sensitivity
Interacting Proteins
- AKT1
- CCNB1
- CDK1
- CREBBP
- ESR1
- FHL2
- SET
- SIRT1
- Sirt1
- YWHAZ
Pathways
- Cell Cycle
- Localization
- Cell Death
- Cell Proliferation
- Gluconeogenesis
- Secretion
- Aging
- Pathogenesis
- Muscle Atrophy
- Insulin Secretion
- Cell Cycle Arrest
- Glucose Homeostasis
- Cell Growth
PTMs
- Phosphorylation
- Acetylation
- Dephosphorylation
- Oxidation
- Deacetylation
- Cleavage
- Ubiquitination
- Methylation
- Glycosylation
- Reduction
Research Areas
- Apoptosis
- DNA Repair
- Growth and Development
- Neuronal Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXO1
bosterbio.com/bosterbio-gene-info-cards/FOXO1
References
PMID: 8275086 by Galili N., et al. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
PMID: 9479491 by Anderson M.J., et al. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
3 Publications of Boster Forkhead box protein O1 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.ejphar.2020.173136, Prolonged overnutrition with fructose or fat induces metabolic derangements in r...
- PubMed ID: 31836014, Li L,Zhao H,Chen B,Fan Z,Li N,Yue J,Ye Q.FXR activation alleviates tacrolimus-in...
- PubMed ID: 24862853, Dong P, Mai Y, Zhang Z, Mi L, Wu G, Chu G, Yang G, Sun S. Acta Biochim Biophys S...
*More publications can be found for each product on its corresponding product page