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- Table of Contents
FRS2 Antibodies
AND FRS2 ELISA kits, FRS2 Proteins
Many biological assays use antibodies to detect FRS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FRS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FRS2 antibodies...
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FRS2 Infographic by Boster Bio
All FRS2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1226
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1226
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2597
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2597
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse
ELISA, IF, IHC, WB
$380
Cat # A02798Y436
100ul
Cat # A02798Y436
100ul
FRS2 Overview
Facts about Fibroblast growth factor receptor substrate 2.
Fibroblast growth factor receptor substrate 2 (FRS2)
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in reaction to ligand-mediated activation of FGFR1.
Modulates indicating via SHC1 by competing for a common binding site on NTRK1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FRS2 |
| Uniprot: | Q8WU20 |
| Entrez: | 10818 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FGFR signalling adaptor; FGFR-signaling adaptor SNT; fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT1; SNT-1FGFR substrate 2; Suc1-associated neurotrophic factor target 1
Molecular Weight
Mass (kDA):
57.029 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q15 |
| Sequence: | 12; NC_000012.12 (69470371..69579793) |
Tissue Specificity
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Subcellular Localizations
Endomembrane system. Cytoplasmic, membrane-bound.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Tumor Angiogenesis
- Neuroblastoma
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Endocrine Gland Neoplasms
- Multiple Endocrine Neoplasia
- Nervousness
Interacting Proteins
- PTPN11
Pathways
- Cell Proliferation
- Localization
- Angiogenesis
- Cell Migration
- Cell Growth
- Cell Differentiation
- Cell Cycle
- Cell Death
- Tube Formation
- Chemotaxis
- Cell Adhesion
- Mesoderm Formation
- Ossification
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRS2
bosterbio.com/bosterbio-gene-info-cards/FRS2
References
PMID: 9660748 by Xu H., et al. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
PMID: 10092678 by Meakin S.O., et al. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.