Fam89b Antibodies

AND Fam89b ELISA kits, Fam89b Proteins

Many biological assays use antibodies to detect Fam89b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fam89b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fam89b antibodies...

We validate the specificity of these antibodies to Fam89b by testing them on tissues known to express Fam89b positively and negatively. Browse below to find the Fam89b antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Fam89b Infographic by Boster Bio

All Fam89b Products

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FAM89B (NM_001098785) Human Recombinant Protein

Coomassie blue staining of purified FAM89B protein

$1249
Cat # PROTQ8N5H3
20 µg

FAM89B (NM_001098785) Human Over-expression Lysate

FAM89B Human Over-expression Lysates NM_001098784

Human

$628
Cat # LS023625
20 µg, 100 µg

Fam89b Overview

Facts about Leucine repeat adapter protein 25.

Leucine repeat adapter protein 25 (Fam89b)

Negatively regulates TGF-beta-induced signaling; in collaboration with SKI prevents the translocation of SMAD2 in the nucleus to the cytoplasm in response to TGF-beta (PubMed:12646588). Acts as an adapter which mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB from the lamellipodia.

LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 that's important for lamellipodial F- actin regulation (PubMed:25107909). .

Gene Information

Mouse
Gene Name:	Fam89b
Uniprot:	Q9QUI1
Entrez:	17826

Family

Belongs to:

FAM89 family

Alternative Names

family with sequence similarity 89, member B; mammary tumor virus receptor homolog 1; MTVR1

Molecular Weight

Mass (kDA):
20.14 kDA

Genomic Context


Mouse

Location:	19 A\|19 4.34 cM
Sequence:	19;

Tissue Specificity

Widely expressed. Expressed in the early postnatal brain.

Diseases

Neoplasms
Malignant Neoplasms
Colorectal Neoplasms
Mammary Neoplasms
Cytogenetic Abnormality
Colorectal Cancer

Carcinoma

Pathways

Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fam89b

References

PMID: 10512749 by Sakuma-Takagi M., et al. Novel related cDNAs (C184L, C184M, and C184S) from developing mouse brain encoding two apparently unrelated proteins.

PMID: 9525630 by Golovkina T.V., et al. A novel membrane protein is a mouse mammary tumor virus receptor.