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- Table of Contents
Facts about F-box only protein 5.
During G1 phase, plays a role as portion of APC-FZR1 complicated E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complicated during S and G2 resulting in cell- cycle commitment (PubMed:29875408).
| Human | |
|---|---|
| Gene Name: | FBXO5 |
| Uniprot: | Q9UKT4 |
| Entrez: | 26271 |

| Belongs to: |
|---|
| No superfamily |

EMI1Early mitotic inhibitor 1; F-box only protein 5; F-box protein 5; FBX5F-box protein Fbx5; Fbxo31
Mass (kDA):
50.146 kDA

| Human | |
|---|---|
| Location: | 6q25.2 |
| Sequence: | 6; NC_000006.12 (152970535..152983579, complement) |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984).





PMID: 10531035 by Cenciarelli C., et al. Identification of a family of human F-box proteins.
PMID: 11988738 by Hsu J.Y., et al. E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).