This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Fbxw7 Antibodies
AND Fbxw7 ELISA kits, Fbxw7 Proteins
Many biological assays use antibodies to detect Fbxw7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Fbxw7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Fbxw7 antibodies...
Designing a Western blot for Fbxw7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the FBXW7 Western Blot GuideFbxw7 Infographic by Boster Bio
All Fbxw7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00406-2
100 μg/vial
Cat # A00406-2
100 μg/vial
Fbxw7 Overview
Facts about F-box/WD repeat-containing protein 7.
F-box/WD repeat-containing protein 7 (Fbxw7)
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them into the SCF complex for ubiquitination (By similarity).
Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and likely PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Fbxw7 |
| Uniprot: | Q8VBV4 |
| Entrez: | 50754 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AGO; AGOFBXO30; Archipelago Homolog; archipelago, Drosophila, homolog of; Cdc4; CDC4FLJ16457; F-box and WD repeat domain containing 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FBW6; Fbw7; FBW7hCdc4; FBX30; FBX30FLJ11071; FBXO30; FBXW6; FBXW7; hAgo; homolog of C elegans sel-10; SCF(Fbw7); SEL10; SEL-10DKFZp686F23254; SEL10FBW6
Molecular Weight
Mass (kDA):
79.848 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3 F1|3 37.7 cM |
| Sequence: | 3; |
Tissue Specificity
Widely expressed with highest levels in brain, heart and testis.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Acute Lymphocytic Leukemia
- Carcinoma
- Mammary Neoplasms
- Colorectal Neoplasms
- Lymphoma
- Colorectal Cancer
- Malignant Neoplasm Of Breast
- Adenocarcinoma
Pathways
- Cell Cycle
- Proteolysis
- Cell Proliferation
- Pathogenesis
- Cell Growth
- S Phase
- Cell Division
- Localization
- Oncogenesis
- Mitosis
- Cell Differentiation
- Notch Signaling Pathway
- Dna Replication
PTMs
- Phosphorylation
- Ubiquitination
- Methylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fbxw7
bosterbio.com/bosterbio-gene-info-cards/Fbxw7
References
PMID: 11735228 by Maruyama S., et al. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
PMID: 11425854 by Gupta-Rossi N., et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.