ADP-ribosylation factor-binding protein GGA3 (GGA3)

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules using a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005).

Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). Nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053).