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Gamma-glutamyl hydrolase Antibodies
AND GGH ELISA kits, Gamma-glutamyl hydrolase Proteins
Many biological assays use antibodies to detect Gamma-glutamyl hydrolase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gamma-glutamyl hydrolase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gamma-glutamyl hydrolase antibodies...
Designing a Western blot for Gamma-glutamyl hydrolase? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GGH Western Blot GuideGGH Infographic by Boster Bio
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GGH Overview
Facts about Gamma-glutamyl hydrolase.
Gamma-glutamyl hydrolase (GGH)
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate.
May play an essential role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GGH |
| Uniprot: | Q92820 |
| Entrez: | 8836 |
Family
| Belongs to: |
|---|
| peptidase C26 family |
Alternative Names
Conjugase; EC 3.4.19.9; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; GH
Molecular Weight
Mass (kDA):
35.964 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.3 |
| Sequence: | 8; NC_000008.11 (63015079..63038806, complement) |
Subcellular Localizations
Secreted, extracellular space. Lysosome. Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Diseases
- Malignant Neoplasms
- Neoplasms
- Leukemia
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Acute Lymphocytic Leukemia
- Carcinoma
- Arthritis
- Malignant Neoplasm Of Lung
- Colorectal Cancer
- Rheumatoid Arthritis
- Hepatitis
- Colorectal Neoplasms
- Lung Neoplasms
Pathways
- Transport
- Secretion
- Methylation
- Cell Adhesion
- Aging
- Fermentation
- Bone Mineralization
- Glycosylation
- Localization
- Programmed Cell Death
- Cellular Homeostasis
- Neurogenesis
- Response To Methotrexate
PTMs
- Cleavage
- Methylation
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GGH
bosterbio.com/bosterbio-gene-info-cards/GGH
References
PMID: 8816764 by Yao R., et al. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.
PMID: 10570974 by Yin D., et al. Structural organization of the human gamma-glutamyl hydrolase gene.