GLDC Antibodies

AND GLDC ELISA kits, GLDC Proteins

Many biological assays use antibodies to detect GLDC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GLDC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GLDC antibodies...

We validate the specificity of these antibodies to GLDC by testing them on tissues known to express GLDC positively and negatively. Browse below to find the GLDC antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GLDC Infographic by Boster Bio

All GLDC Products

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Product

Figures

Specificity

Applications

Price

Anti-GLDC Antibody

Western blot analysis of extracts of various cell lines, using GLDC antibody at 1:1000 dilution

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$405
Cat # A04777
100ul

Anti-Glycine decarboxylase/GLDC Antibody Picoband®

1 Citations

Western blot analysis of Glycine decarboxylase/GLDC using anti-Glycine decarboxylase/GLDC antibody (A04777-2)

IHC analysis of Glycine decarboxylase/GLDC using anti-Glycine decarboxylase/GLDC antibody (A04777-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04777-2
100 μg/vial

Anti-Glycine decarboxylase/GLDC Antibody Picoband® (monoclonal, 3D3D3)

1 Citations

Western blot analysis of GLDC using anti-GLDC antibody (M04777)

IHC analysis of GLDC using anti-GLDC antibody (M04777)

Human, Mouse, Rat

IHC, WB

$370
Cat # M04777
100 μg/vial

GLDC Overview

Facts about Glycine dehydrogenase (decarboxylating), mitochondrial.

GLDC 3D structure. Source: alphafold

Glycine dehydrogenase (decarboxylating), mitochondrial (GLDC)

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

Gene Information

Human
Gene Name:	GLDC
Uniprot:	P23378
Entrez:	2731

Family

Belongs to:

GcvP family

Alternative Names

EC 1.4.4.2; GCE; GCSPMGC138198; Glycine cleavage system P protein; glycine cleavage system protein P; glycine decarboxylase P-protein; Glycine decarboxylase; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavagesystem protein P); glycine dehydrogenase [decarboxylating], mitochondrial; HYGN1; MGC138200; NKH

Molecular Weight

Mass (kDA):
112.73 kDA

Genomic Context


Human

Location:	9p24.1
Sequence:	9; NC_000009.12 (6532467..6645729, complement)

Subcellular Localizations

Mitochondrion.

Diseases

Nonketotic Hyperglycinemia
Hyperglycinemia
Encephalopathies
Muscle Hypotonia
Neoplasms
Apnea
Brain Diseases
Disorder Of Glycine Metabolism
Inborn Errors Of Metabolism
Neonatal Hypotonia
Moderate Mental Retardation

Personality Disorders
Learning Disabilities
Hypoxia
Behavioral Tic
Dyskinetic Syndrome
Malignant Neoplasms

Pathways

Tube Closure
Neural Tube Closure
Cell Proliferation
Translation
Pathogenesis
Glycolysis

Excretion

PTMs

Cleavage

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLDC

References

PMID: 1996985 by Kure S., et al. Structural and expression analyses of normal and mutant mRNA encoding glycine decarboxylase: three-base deletion in mRNA causes nonketotic hyperglycinemia.

PMID: 1993704 by Kume A., et al. The glycine cleavage system. Molecular cloning of the chicken and human glycine decarboxylase cDNAs and some characteristics involved in the deduced protein structures.