12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (GPR31)

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive mobile access to the subendothelial matrix, which is a critical step for extravasation or metastasis.

Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. .