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Acts as a transcription coactivator in adipocytes by encouraging the recruitment of PPARG to promoters: functions by inhibiting the activity of this ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530).
|Sequence:||17; NC_000017.11 (7312661..7315360, complement)|
Nucleus. Mitochondrion. Cytoplasm, cytosol. Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity).