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- Table of Contents
GRB7 Antibodies
AND GRB7 ELISA kits, GRB7 Proteins
Many biological assays use antibodies to detect GRB7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRB7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRB7 antibodies...
Designing a Western blot for GRB7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the GRB7 Western Blot GuideGRB7 Infographic by Boster Bio
All GRB7 Products
Product
Figures
Specificity
Applications
Price
Anti-GRB7 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PA1589-1
100 μg/vial
Cat # PA1589-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02528
100 µl
Cat # M02528
100 µl
GRB7 Overview
Facts about Growth factor receptor-bound protein 7.
Growth factor receptor-bound protein 7 (GRB7)
Promotes activation of down-stream protein kinases, such as STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS.
Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | GRB7 |
| Uniprot: | Q14451 |
| Entrez: | 2886 |
Family
| Belongs to: |
|---|
| GRB7/10/14 family |
Alternative Names
B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; growth factor receptor-bound protein 7
Molecular Weight
Mass (kDA):
59.681 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (39737938..39747285) |
Subcellular Localizations
Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Cell projection. Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Stomach
- Stomach Neoplasms
- Esophageal Neoplasms
Interacting Proteins
- AR
- EPHB1
- ERBB2
- ERBB3
- HAX1
- KCTD6
- KIT
- LAX1
- OLIG1
- PDGFRB
Pathways
- Cell Migration
- Cell Proliferation
- Localization
- Regulation Of Cell Migration
- Translation
- Cell Cycle
- Pathogenesis
- Cell Adhesion
- Transport
- Cell Motility
- Oncogenesis
- Cell Development
- Dna Amplification
PTMs
- Phosphorylation
- Biotinylation
- Ubiquitination
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRB7
bosterbio.com/bosterbio-gene-info-cards/GRB7
References
PMID: 9125150 by Kishi T., et al. Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer.
PMID: 9710451 by Tanaka S., et al. A novel variant of human Grb7 is associated with invasive esophageal carcinoma.
1 Publications of Boster GRB7 Antibodies & ELISA Kits
- PubMed ID: 26617853, Grb7 gene amplification and protein expression by FISH and IHC in ovarian cancer
*More publications can be found for each product on its corresponding product page