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- Table of Contents
GRHL1 Antibodies
AND GRHL1 ELISA kits, GRHL1 Proteins
Many biological assays use antibodies to detect GRHL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRHL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRHL1 antibodies...
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GRHL1 Infographic by Boster Bio
All GRHL1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07368-1
100 μg/vial
Cat # A07368-1
100 μg/vial
$1062
Cat # PROTQ9NZI5
20 µg
Cat # PROTQ9NZI5
20 µg
Human
$628
Cat # LS029841
20 µg, 100 µg
Cat # LS029841
20 µg, 100 µg
GRHL1 Overview
Facts about Grainyhead-like protein 1 homolog.
Grainyhead-like protein 1 homolog (GRHL1)
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642).
Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | GRHL1 |
| Uniprot: | Q9NZI5 |
| Entrez: | 29841 |
Family
| Belongs to: |
|---|
| grh/CP2 family |
Alternative Names
grainyhead-like 1 (Drosophila); grainyhead-like protein 1 homolog; LBP protein 32; MGRLBP-32; NH32; TFCP2L2; Transcription factor CP2-like 2LBP32Mammalian grainyhead; Transcription factor LBP-32
Molecular Weight
Mass (kDA):
70.113 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (9951693..10002279) |
Tissue Specificity
Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non- steroidogenic cells.
Subcellular Localizations
Nucleus.
Diseases
- Tissue Adhesions
- Exencephaly
- Palmoplantar Keratosis
- Flushing
- Neoplasms
- Spina Bifida
- Gastroesophageal Reflux Disease
Pathways
- Neural Tube Closure
- Cell Proliferation
- Localization
- Tube Closure
- Cell Cycle
- Wound Healing
- Transport
- Cell Adhesion
- Lipid Localization
- Endoderm Development
- Organic Acid Transport
- Dorsal Closure
- Dna Repair
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRHL1
bosterbio.com/bosterbio-gene-info-cards/GRHL1
References
PMID: 10644752 by Huang N., et al. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc.
PMID: 12175488 by Wilanowski T., et al. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead.