Glutamate receptor 3 (GRIA3)

Receptor for glutamate that acts as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, resulting in the opening of the cation channel, and thereby transforms the chemical signal to an electrical impulse. The receptor then desensitizes quickly and enters a transient inactive state, characterized by the presence of bound agonist.