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GRIN2D Antibodies
AND GRIN2D ELISA kits, GRIN2D Proteins
Many biological assays use antibodies to detect GRIN2D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRIN2D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRIN2D antibodies...
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GRIN2D Infographic by Boster Bio
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GRIN2D Overview
Facts about Glutamate receptor ionotropic, NMDA 2D.
Glutamate receptor ionotropic, NMDA 2D (GRIN2D)
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851).
Sensitivity to glutamate and channel kinetics are determined by the subunit composition (PubMed:9489750). .
Gene Information
| Human | |
|---|---|
| Gene Name: | GRIN2D |
| Uniprot: | O15399 |
| Entrez: | 2906 |
Family
| Belongs to: |
|---|
| glutamate-gated ion channel (TC 1.A.10.1) family |
Alternative Names
EB11estrogen receptor binding CpG island; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA epsilon 4; NMDAR2DN-methyl-d-aspartate receptor subunit 2D; N-methyl D-aspartate receptor subtype 2D; NR2Dglutamate [NMDA] receptor subunit epsilon-4
Molecular Weight
Mass (kDA):
143.752 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (48394875..48444937) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Diseases
- Schizophrenia
- Psychotic Disorders
- Pcp - Hallucinogen-related Disorder
- Malignant Neoplasm Of Breast
- Idiopathic Pneumonia Syndrome
- De Novo Mutation
- Lordosis
- Pregnancy Complications, Infectious
- Cancer Patients And Suicide And Depression
- Epilepsy
Interacting Proteins
- Dlg3
Pathways
- Brain Development
- Localization
- Pathogenesis
- Reproductive Behavior
PTMs
- Disulfide bond
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRIN2D
bosterbio.com/bosterbio-gene-info-cards/GRIN2D
References
PMID: 9489750 by Hess S.D., et al. Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors.
PMID: 27616483 by Li D., et al. GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers.