GRM4 Antibodies

AND GRM4 ELISA kits, GRM4 Proteins

Many biological assays use antibodies to detect GRM4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRM4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRM4 antibodies...

We validate the specificity of these antibodies to GRM4 by testing them on tissues known to express GRM4 positively and negatively. Browse below to find the GRM4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRM4 Infographic by Boster Bio

All GRM4 Products

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Product

Figures

Specificity

Applications

Price

mGluR4 Colorimetric Cell-Based ELISA Kit

Western blot analysis of extracts from 293 cells

Human, Mouse, Rat

ELISA

$480
Cat # EKC1366
1 kit, containing one 96-well plate and all necessary reagents

Anti-Metabotropic Glutamate Receptor 4 (GRM4) Mouse Monoclonal Antibody [Clone ID: OTI6D1]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GRM4 (Right lane) cDNA for 48 hrs and lysed

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum within the normal limits using anti-GRM4 mouse monoclonal antibody

Human, Mouse, Rat

IHC, WB

$523
Cat # M06552
100 µl

Metabotropic Glutamate Receptor 4 (GRM4) (NM_000841) Human Over-expression Lysate

Human

$960
Cat # LS002914
20 µg, 100 µg

GRM4 Overview

Facts about Metabotropic glutamate receptor 4.

GRM4 3D structure. Source: alphafold

Metabotropic glutamate receptor 4 (GRM4)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Signaling inhibits adenylate cyclase activity. .

Gene Information

Human
Gene Name:	GRM4
Uniprot:	Q14833
Entrez:	2914

Family

Belongs to:

G-protein coupled receptor 3 family

Alternative Names

glutamate receptor, metabotropic 4; GPRC1D; GPRC1Dmetabotropic glutamate receptor 4; GRM4; MGC177594; mGlu4; mGluR4; MGLUR4glutamate metabotropic receptor 4

Molecular Weight

Mass (kDA):
101.868 kDA

Genomic Context


Human

Location:	6p21.31
Sequence:	6; NC_000006.12 (34018643..34155622, complement)

Tissue Specificity

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Schizophrenia
Bipolar Disorder
Epilepsy
Epilepsy, Generalized
Myoclonic Epilepsy, Juvenile
Mental Disorders
Epilepsies, Myoclonic
Depressive Disorder
Schizoaffective Disorder
Mood Disorders
Idiopathic Generalized Epilepsy
Leukoencephalopathies

Endoplasmic Reticulum Stress
Epilepsy, Reflex
Caprine Arthritis-encephalitis
5,10-methylenetetrahydrofolate Reductase Deficiency
Peste Des Petits Ruminants Infection
Dysequilibrium Syndrome

Pathways

Translation
Circadian Rhythm
Synaptic Transmission
Taste Perception

PTMs

Phosphorylation

Research Areas

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRM4

References

PMID: 8738157 by Makoff A., et al. Molecular characterization and localization of human metabotropic glutamate receptor type 4.

PMID: 9473604 by Wu S., et al. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.