Hcn1 Antibodies

AND Hcn1 ELISA kits, Hcn1 Proteins

Many biological assays use antibodies to detect Hcn1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hcn1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hcn1 antibodies...

We validate the specificity of these antibodies to Hcn1 by testing them on tissues known to express Hcn1 positively and negatively. Browse below to find the Hcn1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Hcn1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the HCN1 Western Blot Guide

Hcn1 Infographic by Boster Bio

All Hcn1 Products

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Anti-HCN1 Antibody Picoband®

Western blot analysis of HCN1 using anti-HCN1 antibody (PB9210)

Human, Mouse, Rat

$370
Cat # PB9210
100 μg/vial

Hcn1 Overview

Facts about Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1.

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Hcn1)

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).

May mediate responses to sour stimuli. .

Gene Information

Mouse
Gene Name:	Hcn1
Uniprot:	O88704
Entrez:	15165

Family

Belongs to:

potassium channel HCN family

Alternative Names

BCNG1; BCNG-1brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; HAC-2; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Molecular Weight

Mass (kDA):
102.432 kDA

Genomic Context


Mouse

Location:	13 D2.3\|13 66.34 cM
Sequence:	13;

Tissue Specificity

Predominantly expressed in brain. Highly expressed in apical dendrites of pyramidal neurons in the cortex, in the layer corresponding to the stratum lacunosum-moleculare in the hippocampus and in axons of basket cells in the cerebellum. Expressed in a subset of elongated cells in taste buds.

Diseases

Epilepsy
Epilepsy, Temporal Lobe
Cardiac Arrhythmia
Nervousness
Pain
Absence Epilepsy
Depressive Disorder
Channelopathies
Malnutrition
Epilepsy, Generalized
Febrile Convulsions
Status Epilepticus

Neuralgia
Albinism
Heart Failure
Bradycardia
Malignant Neoplasms
Nerve Damage
Sclerosis

Pathways

Localization
Membrane Hyperpolarization
Synaptic Transmission
Cell Cycle
Glycosylation
Cardiac Conduction
Cognition
Pathogenesis
Response To Camp
Aging
Hypersensitivity
Anaphase
Reflex

Reverse Transcription
Endocytosis
Metaphase
Conjugation
Cell Death
Transport
Cell Migration

PTMs

Phosphorylation
Glycosylation

Acetylation
Dephosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hcn1

References

PMID: 9405696 by Santoro B., et al. Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

PMID: 9634236 by Ludwig A., et al. A family of hyperpolarization-activated cation channels.