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- Table of Contents
Facts about E3 ubiquitin-protein ligase HECW1.
Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that cause motor neuron death in FALS. .
Human | |
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Gene Name: | HECW1 |
Uniprot: | Q76N89 |
Entrez: | 23072 |
Belongs to: |
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No superfamily |
C2 and WW domain-containing protein 1; HECT type E3 ubiquitin ligase; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; NEDD4-like E3 ubiquitin-protein ligase 1; NEDL1
Mass (kDA):
179.554 kDA
Human | |
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Location: | 7p14.1-p13 |
Sequence: | 7; NC_000007.14 (43112580..43566001) |
Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Cytoplasm.
PMID: 14684739 by Miyazaki K., et al. NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.