HEYL Antibodies

AND HEYL ELISA kits, HEYL Proteins

Many biological assays use antibodies to detect HEYL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HEYL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HEYL antibodies...

We validate the specificity of these antibodies to HEYL by testing them on tissues known to express HEYL positively and negatively. Browse below to find the HEYL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HEYL Infographic by Boster Bio

All HEYL Products

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Anti-Hey L (HEYL) Mouse Monoclonal Antibody [Clone ID: OTI4D8]

1 Citations

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HEYL (Right lane) cDNA for 48 hrs and lysed

Human

$523
Cat # M07068
100 µl

Hey L (HEYL) (NM_014571) Human Over-expression Lysate

Human

$628
Cat # LS026508
20 µg, 100 µg

HEYL Overview

Facts about Hairy/enhancer-of-split related with YRPW motif-like protein.

HEYL 3D structure. Source: alphafold

Hairy/enhancer-of-split related with YRPW motif-like protein (HEYL)

Downstream effector of Notch signaling that might be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity).

Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. .

Gene Information

Human
Gene Name:	HEYL
Uniprot:	Q9NQ87
Entrez:	26508

Family

Belongs to:

HEY family

Alternative Names

BHLHB33; bHLHb33hHeyL; Class B basic helix-loop-helix protein 33; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like protein; hairy/enhancer-of-split related with YRPW motif-like; Hairy-related transcription factor 3; HEY3; HEY-like protein; hHRT3; HRT3; HRT-3; MGC12623

Molecular Weight

Mass (kDA):
35.087 kDA

Genomic Context


Human

Location:	1p34.2
Sequence:	1; NC_000001.11 (39623435..39639643, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Pasteurella Infections
Idiopathic Hypereosinophilic Syndrome
Rodent Diseases
Carcinoma
Malignant Neoplasm Of Lung
Malignant Neoplasm Of Stomach
Congenital Heart Defects
Malignant Neoplasm Of Pancreas
Tumor Angiogenesis
Atrophy
Small Cell Carcinoma Of Lung

Hypertrophy
Colorectal Cancer
Neuroblastoma
Crest Syndrome
Malignant Neoplasm Of Breast
Fibrosis
Dermatologic Disorders

Interacting Proteins

MDFI
RBPMS
RPGRIP1

Pathways

Notch Signaling Pathway
Regeneration
Pathogenesis
Neurogenesis
Cell Proliferation
Cell Death
Angiogenesis
Programmed Cell Death
Osteoblast Differentiation
Proteolysis
Cell Fate Determination
Keratinocyte Differentiation
Vasculogenesis

Cell Fate Specification
Fermentation
Cell Cycle
Cell Differentiation
Epithelial Cell Proliferation
Lung Morphogenesis
Somitogenesis

PTMs

Phosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HEYL

References

PMID: 10860664 by Steidl C., et al. Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family.

PMID: 11095750 by Nakagawa O., et al. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.