HHLA2 Antibodies

AND HHLA2 ELISA kits, HHLA2 Proteins

Many biological assays use antibodies to detect HHLA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HHLA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HHLA2 antibodies...

We validate the specificity of these antibodies to HHLA2 by testing them on tissues known to express HHLA2 positively and negatively. Browse below to find the HHLA2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HHLA2 Infographic by Boster Bio

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HHLA2 Overview

Facts about HERV-H LTR-associating protein 2.

HHLA2 3D structure. Source: alphafold

HERV-H LTR-associating protein 2 (HHLA2)

Through Discussion with TMIGD2, costimulates T-cells in the context of TCR-mediated activation.
Enhances T-cell proliferation and cytokine production through an AKT-dependent signaling cascade.

Gene Information

Human
Gene Name:	HHLA2
Uniprot:	Q9UM44
Entrez:	11148

Family

Belongs to:

No superfamily

Alternative Names

B7H7; B7-H7; HERV-H LTR-associating 2; HERV-H LTR-associating protein 2; HHLA2; Human endogenous retrovirus-H long terminal repeat-associating protein 2

Molecular Weight

Mass (kDA):
46.85 kDA

Genomic Context


Human

Location:	3q13.13
Sequence:	3; NC_000003.12 (108296490..108378285)

Tissue Specificity

Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B- cells, dendritic cells and macrophages. Not detected in T-cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HHLA2

References

PMID: 10444326 by Mager D.L., et al. Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3).

PMID: 23784006 by Zhu Y., et al. B7-H5 costimulates human T cells via CD28H.