Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol.

In intact cells, the reaction runs only in one direction, from 7- ketocholesterol into 7-beta-hydroxycholesterol (By similarity). .