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HSD11B1 Antibodies
AND HSD11B1 ELISA kits, HSD11B1 Proteins
Many biological assays use antibodies to detect HSD11B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD11B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD11B1 antibodies...
Designing a Western blot for HSD11B1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HSD11B1 Western Blot GuideHSD11B1 Infographic by Boster Bio
All HSD11B1 Products
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HSD11B1 Overview
Facts about Corticosteroid 11-beta-dehydrogenase isozyme 1.
Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol.
In intact cells, the reaction runs only in one direction, from 7- ketocholesterol into 7-beta-hydroxycholesterol (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | HSD11B1 |
| Uniprot: | P28845 |
| Entrez: | 3290 |
Family
| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |
Alternative Names
11 betaHSD1; 11 beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; EC 1.1.1; EC 1.1.1.146; HDL; HSD11B1; HSD11HSD11B; HSD11LMGC13539; hydroxysteroid (11-beta) dehydrogenase 1; member 1; SDR26C1
Molecular Weight
Mass (kDA):
32.401 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.2 |
| Sequence: | 1; NC_000001.11 (209686180..209734950) |
Tissue Specificity
Widely expressed. Highest expression in liver.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Diseases
- Obesity
- Diabetes Mellitus
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Hypertensive Disease
- Insulin Sensitivity
- Malignant Neoplasms
- Cushing Syndrome
- Metabolic Syndrome X
- Polycystic Ovary Syndrome
- Inflammation
- Obesity, Abdominal
- Deficiency Of (r)-20-hydroxysteroid Dehydrogenase
Pathways
- Secretion
- Pathogenesis
- Regeneration
- Excretion
- Aging
- Ovulation
- Transport
- Insulin Secretion
- Glycosylation
- Localization
- Gluconeogenesis
- Inflammatory Response
- Phagocytosis
PTMs
- Cleavage
- Phosphorylation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD11B1
bosterbio.com/bosterbio-gene-info-cards/HSD11B1
References
PMID: 1885595 by Tannin G.M., et al. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.
PMID: 12414862 by Draper N., et al. Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.