HSD11B1 Antibodies

AND HSD11B1 ELISA kits, HSD11B1 Proteins

Many biological assays use antibodies to detect HSD11B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD11B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD11B1 antibodies...

We validate the specificity of these antibodies to HSD11B1 by testing them on tissues known to express HSD11B1 positively and negatively. Browse below to find the HSD11B1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HSD11B1 Infographic by Boster Bio

All HSD11B1 Products

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Anti-HSD11B1 Antibody Picoband®

7 Q&As

Western blot analysis of HSD11B1 using anti-HSD11B1 antibody (PA1372-1)

IHC analysis of HSD11B1 using anti-HSD11B1 antibody (PA1372-1)

Human, Monkey, Mouse, Rat

IHC, WB

$370
Cat # PA1372-1
100 μg/vial

Anti-HSD11B1 Rabbit Monoclonal Antibody

Western blot analysis of HSD11B1 expression in human fetal liver lysate

Human, Mouse, Rat

IHC, WB

$370
Cat # M01565-1
100 μl/vial

Anti-HSD11B1 Antibody Picoband®

Western blot analysis of HSD11B1 using anti-HSD11B1 antibody (A01565)

Human

ELISA, WB

$370
Cat # A01565
100 μg/vial

HSD11B1 (NM_005525) Human Over-expression Lysate

HSD11B1 Human Over-expression Lysates NM_005525

Human

$628
Cat # LS003290
20 µg, 100 µg

Anti-HSD11B1 Antibody (Monoclonal, 33H66)

Western blot analysis of HSD11B1 using anti-HSD11B1 antibody (M01565-2)

IHC analysis of HSD11B1 using anti-HSD11B1 antibody (M01565-2)

Human, Mouse, Rat

IHC, WB

$370
Cat # M01565-2
100 μl/vial

HSD11B1 Overview

Facts about Corticosteroid 11-beta-dehydrogenase isozyme 1.

HSD11B1 3D structure. Source: alphafold

Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1)

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol.

In intact cells, the reaction runs only in one direction, from 7- ketocholesterol into 7-beta-hydroxycholesterol (By similarity). .

Gene Information

Human
Gene Name:	HSD11B1
Uniprot:	P28845
Entrez:	3290

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

11 betaHSD1; 11 beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; EC 1.1.1; EC 1.1.1.146; HDL; HSD11B1; HSD11HSD11B; HSD11LMGC13539; hydroxysteroid (11-beta) dehydrogenase 1; member 1; SDR26C1

Molecular Weight

Mass (kDA):
32.401 kDA

Genomic Context


Human

Location:	1q32.2
Sequence:	1; NC_000001.11 (209686180..209734950)

Tissue Specificity

Widely expressed. Highest expression in liver.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Diseases

Obesity
Diabetes Mellitus
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Hypertensive Disease
Insulin Sensitivity
Malignant Neoplasms
Cushing Syndrome
Metabolic Syndrome X
Polycystic Ovary Syndrome
Inflammation
Obesity, Abdominal
Deficiency Of (r)-20-hydroxysteroid Dehydrogenase

Neoplasms
Cardiovascular Diseases
Metabolic Diseases
Visceral Obesity
Dyslipidemias
Impaired Glucose Tolerance
Malignant Neoplasm Of Lung

Pathways

Secretion
Pathogenesis
Regeneration
Excretion
Aging
Ovulation
Transport
Insulin Secretion
Glycosylation
Localization
Gluconeogenesis
Inflammatory Response
Phagocytosis

Luteolysis
Cell Proliferation
Parturition
Luteinization
Cell Adhesion
Glucose Homeostasis
Reverse Transcription

PTMs

Cleavage
Phosphorylation

Reduction
Glycosylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD11B1

References

PMID: 1885595 by Tannin G.M., et al. The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

PMID: 12414862 by Draper N., et al. Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.