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- Table of Contents
HSD17B10 Antibodies
AND HSD17B10 ELISA kits, HSD17B10 Proteins
Many biological assays use antibodies to detect HSD17B10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD17B10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD17B10 antibodies...
Designing a Western blot for HSD17B10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HSD17B10 Western Blot GuideHSD17B10 Infographic by Boster Bio
All HSD17B10 Products
Product
Figures
Specificity
Applications
Price
Anti-ERAB/HSD17B10 Antibody Picoband®
1 Citations
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9336
100 μg/vial
Cat # PB9336
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M03844-2
100 µl
Cat # M03844-2
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03844
100 μl
Cat # M03844
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC-P, WB
$299
Cat # M03844-1
50 µl
Cat # M03844-1
50 µl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1198
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1198
1 kit, containing one 96-well plate and all necessary reagents
HSD17B10 Overview
Facts about 3-hydroxyacyl-CoA dehydrogenase type-2.
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)
Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase activity with androsterone (PubMed:9553139, PubMed:23042678, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424). Catalyzes the next step in the beta-oxidation of fatty acids (PubMed:9553139, PubMed:12917011, PubMed:18996107, PubMed:25925575, PubMed:28888424).
Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (PubMed:12917011). Also exhibits 20-beta- OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011).
Gene Information
| Human | |
|---|---|
| Gene Name: | HSD17B10 |
| Uniprot: | Q99714 |
| Entrez: | 3028 |
Family
| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |
Alternative Names
17-beta-HSD 10; 17-beta-hydroxysteroid dehydrogenase 10; 17b-HSD10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; ABAD; amyloid-beta peptide binding alcohol dehydrogenase; CAMR; DUPXp11.22; EC 1.1.1.178; EC 1.1.1.35; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; ERAB3-hydroxyacyl-CoA dehydrogenase type-2; HADH2AB-binding alcohol dehydrogenase; hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme Adehydrogenase, type II; hydroxysteroid (17-beta) dehydrogenase 10; mental retardation, X-linked, syndromic 10; MHBD; Mitochondrial ribonuclease P protein 2,3-hyd
Molecular Weight
Mass (kDA):
26.923 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.22 |
| Sequence: | X; NC_000023.11 (53431258..53434376, complement) |
Tissue Specificity
Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.
Subcellular Localizations
Mitochondrion.
Diseases
- Alzheimer's Disease
- Nerve Degeneration
- Neurotoxicity Syndromes
- Neurodegenerative Disorders
- Choreoathetosis
- Abnormal Behavior
- Mitochondrial Damage
- Malignant Neoplasms
- Hypoglycemia
- Malignant Paraganglionic Neoplasm
- 3-hydroxyacyl-coa Dehydrogenase, Type 2, Deficiency
- Plaque, Amyloid
Interacting Proteins
- APP
- EEF2
- TRAP1
- TRMT10C
Pathways
- Pathogenesis
- Localization
- Cell Death
- Fatty Acid Oxidation
- Transport
- Fatty Acid Beta-oxidation
- Secretion
- Secretory Pathway
- Programmed Cell Death
- Insulin Secretion
- Brain Development
- Aging
- Proteolysis
PTMs
- Oxidation
Research Areas
- Cancer
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD17B10
bosterbio.com/bosterbio-gene-info-cards/HSD17B10
References
PMID: 9338779 by Yan S.D., et al. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
PMID: 9671743 by Miller A.P., et al. Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation.