NADPH-dependent 3-keto-steroid reductase Hsd3b5 (Hsd3b5)

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH.

Does not function as an isomerase. .