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- Table of Contents
Hipk2 Antibodies
AND Hipk2 ELISA kits, Hipk2 Proteins
Many biological assays use antibodies to detect Hipk2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hipk2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hipk2 antibodies...
Designing a Western blot for Hipk2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the HIPK2 Western Blot GuideHipk2 Infographic by Boster Bio
All Hipk2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M01371
100 μl/vial
Cat # M01371
100 μl/vial
Hipk2 Overview
Facts about Homeodomain-interacting protein kinase 2.
Homeodomain-interacting protein kinase 2 (Hipk2)
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, such as SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors.
Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both in the transcription level and at the protein level (by phosphorylation and indirect acetylation).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Hipk2 |
| Uniprot: | Q9QZR5 |
| Entrez: | 15258 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp686K02111; EC 2.7.11.1; FLJ23711; hHIPk2; HIPK2; homeodomain interacting protein kinase 2; homeodomain-interacting protein kinase 2; PRO0593; Stank
Molecular Weight
Mass (kDA):
130.498 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6|6 B1 |
| Sequence: | 6; |
Tissue Specificity
Ubiquitous. Abundant in muscle, heart, small intestine, stomach, kidney and brain; and low in testis, skin and lung.
Diseases
- Neoplasms
- Malignant Neoplasms
- Leukemia
- Carcinoma
- Hypoxia
- Tumor Progression
- Cell Transformation, Neoplastic
- Acute Promyelocytic Leukemia
- Mammary Neoplasms
- Genotoxic Stress
- Carcinogenesis
- Malignant Squamous Cell Neoplasm
Pathways
- Localization
- Rna Interference
- Cell Proliferation
- Cell Death
- Cell Growth
- Cell Cycle
- Pathogenesis
- Cell Differentiation
- Cell Cycle Arrest
- Angiogenesis
- Nuclear Export
- Induction Of Apoptosis
- Senescence
PTMs
- Phosphorylation
- Ubiquitination
- Acetylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Hipk2
bosterbio.com/bosterbio-gene-info-cards/Hipk2
References
PMID: 9748262 by Kim Y.H., et al. Homeodomain-interacting protein kinases, a novel family of co- repressors for homeodomain transcription factors.
PMID: 11078605 by Wang W., et al. Identification and cloning of a CD43-associated serine/threonine kinase.