ICE1 Antibodies

AND ICE1 ELISA kits, ICE1 Proteins

Many biological assays use antibodies to detect ICE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ICE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ICE1 antibodies...

We validate the specificity of these antibodies to ICE1 by testing them on tissues known to express ICE1 positively and negatively. Browse below to find the ICE1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ICE1 Infographic by Boster Bio

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ICE1 Overview

Facts about Little elongation complex subunit 1.

ICE1 3D structure. Source: alphafold

Little elongation complex subunit 1 (ICE1)

Component of the tiny elongation complex (LEC), a complex necessary to control small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically functions as a scaffold protein that promotes the LEC complex formation and recruiting and RNA polymerase II occupancy in snRNA genes in subnuclear bodies (PubMed:23932780).

Gene Information

Human
Gene Name:	ICE1
Uniprot:	Q9Y2F5
Entrez:	23379

Family

Belongs to:

ICE1 family

Alternative Names

Uncharacterized Protein KIAA0947

Molecular Weight

Mass (kDA):
247.891 kDA

Genomic Context


Human

Location:	5p15.32
Sequence:	5; NC_000005.10 (5422673..5490220)

Subcellular Localizations

Nucleus. Nucleus, Cajal body. Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Associates to transcriptionally active chromatin at snRNA genes.

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ICE1

References

PMID: 22195968 by Smith E.R., et al. The little elongation complex regulates small nuclear RNA transcription.

PMID: 23932780 by Hu D., et al. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.