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- Table of Contents
ID1 Antibodies
AND ID1 ELISA kits, ID1 Proteins
Many biological assays use antibodies to detect ID1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ID1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ID1 antibodies...
Designing an IHC experiment for ID1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ID1 IHC GuideID1 Infographic by Boster Bio
All ID1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00945
100 μl
Cat # M00945
100 μl
ID1 Overview
Facts about DNA-binding protein inhibitor ID-1.
DNA-binding protein inhibitor ID-1 (ID1)
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the simple helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | ID1 |
| Uniprot: | P41134 |
| Entrez: | 3397 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHB24; bHLHb24DNA-binding protein inhibitor ID-1; Class B basic helix-loop-helix protein 24; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helixprotein); dJ857M17.1.2; ID; ID1; inhibitor of differentiation 1; Inhibitor of DNA binding 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Molecular Weight
Mass (kDA):
16.133 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.21 |
| Sequence: | 20; NC_000020.11 (31605289..31606510) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Lymphohistiocytosis, Hemophagocytic
- Tumor Angiogenesis
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Pathologic Neovascularization
- Malignant Neoplasm Of Breast
- Cell Invasion
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
Interacting Proteins
- CASK
- CAV1
- TCF4
Pathways
- Cell Proliferation
- Cell Cycle
- Angiogenesis
- Cell Differentiation
- Cell Growth
- Senescence
- Localization
- Pathogenesis
- Regeneration
- Cell Migration
- Cell Death
- Neurogenesis
- Tube Formation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Deacetylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ID1
bosterbio.com/bosterbio-gene-info-cards/ID1
References
PMID: 8086456 by Deed R.W., et al. Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins.
PMID: 8294468 by Hara E., et al. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.