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- Table of Contents
Facts about Immunoglobulin heavy variable 2-70.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
Human | |
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Gene Name: | IGHV2-70 |
Uniprot: | P01814 |
Entrez: | 28454 |
Belongs to: |
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No superfamily |
Immunoglobulin heavy variable 2-70
Mass (kDA):
13.26 kDA
Human | |
---|---|
Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (106770577..106771020, complement) |
Secreted. Cell membrane.
PMID: 6089186 by Takahashi N., et al. Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region.
PMID: 5449120 by Press E.M., et al. The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains.