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- Table of Contents
Facts about Immunoglobulin lambda variable 3-27.
In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).
Human | |
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Gene Name: | IGLV3-27 |
Uniprot: | P01718 |
Entrez: | 28791 |
Belongs to: |
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No superfamily |
Immunoglobulin lambda variable 3-27
Mass (kDA):
12.165 kDA
Human | |
---|---|
Location: | 22q11.22 |
Sequence: | 22; NC_000022.11 (22668326..22668808) |
Secreted. Cell membrane.
PMID: 5549568 by Ponstingl H., et al. Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones- protein Kern). V. The complete amino acid sequence and its genetic interpretation.
PMID: 11872955 by Lefranc M.P.; Nomenclature of the human immunoglobulin lambda (IGL) genes.