IL12RB2 Antibodies

AND IL12RB2 ELISA kits, IL12RB2 Proteins

Many biological assays use antibodies to detect IL12RB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IL12RB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IL12RB2 antibodies...

We validate the specificity of these antibodies to IL12RB2 by testing them on tissues known to express IL12RB2 positively and negatively. Browse below to find the IL12RB2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IL12RB2 Infographic by Boster Bio

All IL12RB2 Products

Product

Figures

Specificity

Applications

Price

Anti-I12R2 IL12RB2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03189
100ul

IL12RB2 (NM_001559) Human Over-expression Lysate

Human

$628
Cat # LS003595
100 µg

IL12RB2 Overview

Facts about Interleukin-12 receptor subunit beta-2.

IL12RB2 3D structure. Source: alphafold

Interleukin-12 receptor subunit beta-2 (IL12RB2)

Receptor for interleukin-12.
This subunit is the signaling component coupling to the JAK2/STAT4 pathway.

Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Gene Information

Human
Gene Name:	IL12RB2
Uniprot:	Q99665
Entrez:	3595

Family

Belongs to:

type I cytokine receptor family

Alternative Names

IL-12 R beta 2; IL-12 receptor beta 2; IL-12 receptor subunit beta-2; IL12R beta 2; IL-12R subunit beta-2; IL12RB2; IL-12Rb2; IL-12R-beta-2; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; interleukin-12 receptor subunit beta-2

Molecular Weight

Mass (kDA):
97.135 kDA

Genomic Context


Human

Location:	1p31.3
Sequence:	1; NC_000001.11 (67307351..67398724)

Tissue Specificity

Isoform 2 is expressed at similar levels in both naive and activated T-cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Autoimmune Reaction
Autoimmune Diseases
Inflammation
Neoplasms
Experimental Autoimmune Encephalomyelitis
Infective Disorder
Primary Biliary Cirrhosis
Biliary Cirrhosis
Malignant Neoplasms
Arthritis
Liver Cirrhosis
Autoimmunity
Malaria

Sclerosis
Diabetes Mellitus
Leishmaniasis, Cutaneous
Leprosy
Asthma
Encephalomyelitis
Rheumatoid Arthritis

Pathways

Pathogenesis
Immune Response
Cell Differentiation
Secretion
Cell Proliferation
T Cell Differentiation
Cell Development
Cytokine Production
Cell Activation
Inflammatory Response
T Cell Activation
Interferon-gamma Secretion
Innate Immune Response

Methylation
B Cell Differentiation
Cell Adhesion
Gene Silencing
Aging
Interferon-gamma Production
Cytokine Secretion

PTMs

Phosphorylation

Methylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL12RB2

References

PMID: 8943050 by Presky D.H., et al. A functional interleukin 12 receptor complex is composed of two beta- type cytokine receptor subunits.

PMID: 10663559 by van Rietschoten J.G.I., et al. Genomic organization of the human interleukin-12 receptor beta2-chain gene.