Protein IMPACT (Impact)

Translational regulator which ensures constant high levels of translation upon a number of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor therapy and glucose deprivation. Plays a role as a negative regulator of this EIF2AK4/GCN2 kinase activity; impairs GCN1- mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428).

May be required to regulate translation in certain neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory activity on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528).