This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Phosphatidylinositide phosphatase SAC2.
Regulator of TF:TFRC and integrins recycling pathway, can also be involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).
| Human | |
|---|---|
| Gene Name: | INPP5F |
| Uniprot: | Q9Y2H2 |
| Entrez: | 22876 |

| Belongs to: |
|---|
| No superfamily |

EC 3.1.3; EC 3.1.3.-; EC 3.1.3.16; EC 3.1.3.36; FLJ13081; hSAC2; Inositol polyphosphate 5-phosphatase F; inositol polyphosphate-5-phosphatase F; KIAA0966MGC59773; MGC131851; phosphatidylinositide phosphatase SAC2; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 5-phosphatase 2; SAC2MSTPO47
Mass (kDA):
128.407 kDA

| Human | |
|---|---|
| Location: | 10q26.11 |
| Sequence: | 10; NC_000010.11 (119704395..119830482) |
Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).
Membrane, clathrin-coated pit. Early endosome. Recycling endosome. Also found on macropinosomes.




PMID: 11274189 by Minagawa T., et al. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase.
PMID: 17322895 by Trivedi C.M., et al. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.